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kathleen arcaro

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Could African American moms’ breastmilk hold the keys to preventing breast cancer?

6a00e008dc89568834014e88c22018970d-800wiNote:  If you’re an African American nursing mom living anywhere in the country and interested in donating breastmilk for this research, please contact Beth Punska at (413) 545-0813, or email her at epunska@vasci.umass.edu. More information is also at the study website

If you’re not nursing, please consider joining the Love/Avon Army of Women, and select “breast milk study” when asked how you heard about it!

You’ve heard it many times before:  breastfeeding and breastmilk gives your baby important nutritional and immunological support.

But could breastmilk hold the keys to preventing and treating breast cancer?  And could African American moms’ breastmilk be especially important?

It’s clear that African American women have a different pattern of breast cancer than other women.  The U.S. Office on Women’s Health reports, “Research has shown that African-American women are more likely to get a form of breast cancer that spreads more quickly.”

In spite of this difference, black women are also underrepresented in some important research which could get to the bottom of breast cancer risk, prevention, and treatment.

What is this research?  It’s being done by Dr. Kathleen Arcaro at the University of Massachusetts, and it uses breastmilk to assess breast cancer risk.  We’ll explain.

Breast cells are key in breast cancer research, but they’re really hard to get.  You can get a limited number through biopsy or extracting nipple aspirate (ouch!), but neither of these methods sound like much fun to most women.  They also have limitations: breast biopsies only yield cells in a very small area of a breast, and nipple aspirate produces very few cells for analysis.

Enter breastmilk.  It’s been clear for some time that ductal breast cells naturally slough off into breastmilk.  The cells in breastmilk of course come from all ductal areas of the breast, and they’re plentiful – an average of 30,000 per milliliter.

Until very recently the presence of these cells in milk was only an interesting footnote in the literature.  But with the advent of DNA analysis, scientists can now extract DNA from these cells and look for patterns of “methylation” – methyl groups that attach to key parts of our DNA which are thought to regulate its functioning in important ways.

right breastFor example, if a methyl group attaches to your tumor suppressor genes, it can essentially turn them off – kind of like you would a light switch.  This leaves us more vulnerable to the growth of tumors.  In a cancer-prone area of our bodies like the breast, their function is critical.

Knowing this, Dr. Arcaro began looking for breastmilk donations about ten years ago.  Spreading the word through lactation consultants and others (and occasionally stopping a mother on the street), she found many mothers enthusiastic to donate their milk in the name of breast cancer research.  Many viewed their milk donation as a way of fighting the disease which had taken the health and sometimes lives of friends and family members.

Dr. Arcaro’s research has already yielded some important results.  She has found that certain patterns of methylation are correlated with a higher risk of breast cancer.  These findings may pave the way for a personalized breast cancer risk profile for each woman.  It also may lead to new treatments to reverse methylation and prevent breast cancer.  Amazingly, some of the first generation chemotherapy drugs are in fact “anti-methylating” agents – drugs which can actually remove methyl groups from your DNA, allowing your DNA to function properly in the fight against cancer.

But Dr. Arcaro has a problem: the vast majority of her samples have come from white women.  Her goal is to uncover findings that apply to all women. To ensure her findings applicable to women of all races – and because the differences in breast cancer between races needs to be investigated in its own right – she has been working to recruit African American women to donate breastmilk samples.

African American moms can play an important part by donating your own milk for this effort.  It’s easy, quick, and makes a big difference!  Dr. Arcaro’s lab sends moms a kit, a questionnaire and consent form, and moms send it back with their milk.  They’ll send participants $25 in thanks for their time and effort.

UMass onesieFor African American who are not nursing, Dr. Arcaro still needs help!  She’s  urging participation in the Love/Avon Army of Women – a project aiming to recruit one million women to sign up to participate in breast cancer research (if they choose to do so).  Having African American women well represented in the breast cancer research is key, for her research and many others.’  So Dr. Arcaro hopes women will sign up for the Army of Women (and be sure to select “breast milk study” in the drop down menu to help track the impact).

Dr. Arcaro’s lab is one of the few in the world which is consistently investigating the secrets breastmilk holds for our understanding of breast cancer.  You can learn more about Dr. Arcaro’s work, and see if you or mothers you know might qualify for one of her studies, at the website of the UMass Breastmilk Lab, and follow the lab on Facebook, Twitter, and Pinterest.

Fight breast cancer by donating your breast milk!

Could your breastmilk hold the keys to the prevention and treatment of breast cancer?

This Breast Cancer Awareness Month, we’re pleased to share some ground breaking breast cancer research which uses breast milk to unlock the secrets of the disease.  And if you fit the criteria for one of the studies using breast milk, you may be able to donate your own!*

Dr. Kathleen Arcaro at the University of Massachusetts, Amherst, is an environmental toxicologist who analyzes breast milk for clues about breast cancer risk.  In spite of years of breast cancer research, we know little about the reasons why women develop it.  The most widely known risk factors – family history and inherited gene mutations – account for only a small number of the new cases diagnosed each year.

But breast milk might be able to help.  Some of your breast duct cells naturally slough off into your milk.  These cells are incredibly valuable in understanding breast cancer, and they’re also hard to get without an invasive procedure.  But you produce an average of 30,000 per milliliter every time you nurse or pump!

Scientists can now use DNA analysis to examine these breast cells for patterns of “methylation:” the presence of methyl groups which attach to key parts of our DNA such as tumor suppressor genes, and “turn them off,” rendering us less capable of stopping the growth of tumors.  Some forms of methylation, which is related to things like diet, smoking, exposure to toxins, stress, and exercise, can render us more vulnerable to breast cancer.

Since 2009, Dr. Arcaro has been investigating whether breast milk could reveal patterns in breast cancer risk by studying women who had or were planning to have a breast biopsy.  Her research has found that certain patterns of methylation are correlated with a higher risk of breast cancer.

This finding is important because it may allow mothers to one day get a personalized breast cancer risk profile. Even more importantly, the hope is that new treatments may actually be able to reverse methylation, dramatically reducing our risk of breast cancer.

You may have known that your breast milk is amazing for its nutritional and immunological properties, but now you know how it’s a weapon in the war on cancer, too!

* Dr. Arcaro is currently looking for milk camples from 1) African American nursing mothers living anywhere in the country, OR 2) nursing mothers of any race living anywhere in the country who have had a breast biopsy or are expecting to have one, OR 3) mothers of any race living anywhere in the country who have had breast cancer and are now nursing.  To participate, see Dr. Arcaro’s donation page.  If you don’t qualify for one now, please check Dr. Arcaro’s website at another time, as her criteria do change over time.

If you don’t qualify to participate but want to be involved (whether you’re nursing or not), you can register for the Love/Avon Army of Women, which will put you on a list of people willing to be contacted should another opportunity arise.  Dr. Arcaro would appreciate it if you’d select “breast milk study” when asked how you heard about the study.

 

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